Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: a modelling study.

Publication Type:

Journal Article

Authors:

Hallett, Timothy B; Baeten, Jared M; Heffron, Renee; Barnabas, Ruanne; de Bruyn, Guy; Cremin, Íde; Delany, Sinead; Garnett, Geoffrey P; Gray, Glenda; Johnson, Leigh; McIntyre, James; Rees, Helen; Celum, Connie

Source:

PLoS medicine, Volume 8, Issue 11, p.e1001123 (2011)

Keywords:

2011, Consortium Authored Paper

Abstract:

Antiretrovirals have substantial promise for HIV-1 prevention, either as antiretroviral treatment (ART) for HIV-1-infected persons to reduce infectiousness, or as pre-exposure prophylaxis (PrEP) for HIV-1-uninfected persons to reduce the possibility of infection with HIV-1. HIV-1 serodiscordant couples in long-term partnerships (one member is infected and the other is uninfected) are a priority for prevention interventions. Earlier ART and PrEP might both reduce HIV-1 transmission in this group, but the merits and synergies of these different approaches have not been analyzed.