Opening windows to the genome.

Publication Type:

Journal Article


Cell, Volume 137, Issue 3, p.400-2 (2009)


2009, Basic Sciences Division, chromatin, Chromatin Assembly and Disassembly, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Genome, Fungal, Nucleosomes, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, TRANSCRIPTION FACTORS


Recent mapping of nucleosome positioning has added a new dimension to the study of transcriptional regulation. Hartley and Madhani (2009) now demonstrate the power of this approach and show that a chromatin regulator alters nucleosome positioning in the promoters of a large number of genes in the budding yeast Saccharomyces cerevisiae.