Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.

Publication Type:

Journal Article

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 26, Issue 31, p.5060-6 (2008)

Keywords:

14-3-3 Proteins, 2008, ADENOCARCINOMA, Annexin A1, Autoantibodies, Case-Control Studies, Cell Line, Tumor, Early Diagnosis, Humans, Lung Neoplasms, Predictive Value of Tests, Protein Array Analysis, Public Health Sciences Division, Receptors, Laminin, Reproducibility of Results, Ubiquitin Thiolesterase

Abstract:

We have implemented a high throughput platform for quantitative analysis of serum autoantibodies, which we have applied to lung cancer for discovery of novel antigens and for validation in prediagnostic sera of autoantibodies to antigens previously defined based on analysis of sera collected at the time of diagnosis.