Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila.

Publication Type:

Journal Article

Authors:

Berrington, William R; Smith, Kelly D; Skerrett, Shawn J; Hawn, Thomas R

Source:

BMC infectious diseases, Volume 13, p.371 (2013)

Keywords:

Animals, Apoptosis Regulatory Proteins, Bacterial Proteins, Calcium-Binding Proteins, Female, Flagellin, Genomics Core Facility, Host-Pathogen Interactions, Legionella pneumophila, Legionnaires' Disease, Macrophages, Male, MICE, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Signal Transduction, Toll-Like Receptors

Abstract:

Legionella pneumophila (Lp) flagellin activates signaling pathways in murine macrophages that control Lp replication. Nucleotide-binding oligomerization domain (NOD) containing-like receptor (NLR) family, caspase recruitment domain (CARD) containing 4 (NLRC4) and Toll-like Receptor (TLR5) both recognize Lp flagellin in vitro, but whether these two receptors play redundant or separate functional roles in vivo is unknown.