A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses.

Publication Type:

Journal Article

Source:

PLoS computational biology, Volume 10, Issue 2, p.e1003493 (2014)

Keywords:

2014, Basic Sciences Division, Center-Authored Paper, Genomics Core Facility, Human Biology Division, March 2014, Public Health Sciences Division

Abstract:

Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.