Notch ligand Delta-like 1 promotes in vivo vasculogenesis in human cord blood-derived endothelial colony forming cells.

Publication Type:

Journal Article

Authors:

Kim, Hyojin; Huang, Lan; Critser, Paul J; Yang, Zhenyun; Chan, Rebecca J; Wang, Lin; Carlesso, Nadia; Voytik-Harbin, Sherry L; Bernstein, Irwin D; Yoder, Mervin C

Source:

Cytotherapy, Volume 17, Issue 5, p.579-92 (2015)

Abstract:

Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability. Because Notch signaling is critical for embryonic blood vessel formation in utero, we hypothesized that Notch pathway activation may enhance cultured ECFC vasculogenic properties in vivo.