A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells.

Publication Type:

Journal Article

Source:

Journal of medical primatology, Volume 40, Issue 2, p.88-103 (2011)

Keywords:

2011, Animals, Antigens, CD19, Antigens, CD20, CD8-Positive T-Lymphocytes, Cell Culture Techniques, Cell Movement, Cell Survival, Cells, Cultured, Clinical Research Division, CYTOMEGALOVIRUS, Cytomegalovirus Infections, Immunologic Memory, Immunotherapy, Adoptive, Macaca nemestrina, Models, Animal, Neoplasms, Polymerase Chain Reaction

Abstract:

Adoptive immunotherapy with antigen-specific effector T-cell (T(E) ) clones is often limited by poor survival of the transferred cells. We describe here a Macaca nemestrina model for studying transfer of T-cell immunity.