No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.

Publication Type:

Journal Article


Human genetics, Volume 132, Issue 12, p.1427-31 (2013)


2013, Center-Authored Paper, October 2013, Public Health Sciences Division, Specimen Processing Core Facility


Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.