No association between antibodies to sexually transmitted infections and colorectal hyperplastic polyps in men: Minnesota Cancer Prevention Research Unit Polyp Study.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2012)

Keywords:

2012, Center-Authored Paper, July 2012, Public Health Sciences Division, Shared Resources, Specimen Processing Core Facility

Abstract:

BACKGROUND: Oncogenic human papillomaviruses (HPV) are sexually transmitted and linked to several epithelial malignancies, but an association between HPV and colorectal neoplasia is not established. Previously, we reported a 3-fold increase in the odds of colorectal hyperplastic polyps associated with oncogenic HPV seropositivity in men, but detected no HPV DNA in colorectal tissues from these same men. METHODS: To test the reproducibility of our prior HPV antibody results and to explore the hypothesis that colorectal hyperplastic polyps may be associated with sexual behavior in men, we conducted a case-control study of hyperplastic polyps and antibodies to 8 oncogenic HPV types (including 16 and 18), herpes simplex virus-2 (HSV-2), and hepatitis C virus (HCV). Study participants were men, ages 30-74 years, enrolled in the Minnesota Cancer Prevention Research Unit Polyp Study who had an index colonoscopy from 1991-1994 and received a diagnosis of hyperplastic polyps (n=97), or were polyp-free (n=184). Plasma was assessed for antibodies to the 8 oncogenic HPV types, HSV-2, and HCV using a bead-based multiplex assay. RESULTS: The adjusted odds ratio (OR) for the association between hyperplastic polyps and seropositivity to oncogenic HPV (all 8 types combined) was 0.84, 95% confidence interval (CI): 0.44-1.58; for HSV-2, OR=0.98, 95% CI: 0.48-1.99; and for HCV, OR=0.61, 95% CI: 0.11-3.26. CONCLUSIONS: Our study suggested no association between colorectal hyperplastic polyps and antibodies to specific sexually transmitted infections in men.Impact: Factors associated with sexually transmitted infections are unlikely to play a role in the etiology of colorectal hyperplastic polyps in men.