New susceptibility locus for coronary artery disease on chromosome 3q22.3.

Publication Type:

Journal Article


Nature genetics, Volume 41, Issue 3, p.280-2 (2009)


2009, Case-Control Studies, Center-Authored Paper, Chromosomes, Human, Pair 3, Coronary Artery Disease, Genetic Predisposition to Disease, Genome-Wide Association Study, Germany, Hepatocyte Nuclear Factor 1-alpha, Humans, Polymorphism, Single Nucleotide, Public Health Sciences Division, Quantitative Trait Loci, ras Proteins


We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).