New-onset breast tenderness after initiation of estrogen plus progestin therapy and breast cancer risk.

Publication Type:

Journal Article


Archives of internal medicine, Volume 169, Issue 18, p.1684-91 (2009)


2009, Aged, Breast, Breast Neoplasms, Center-Authored Paper, Estrogen Replacement Therapy, Estrogens, Conjugated (USP), Female, Humans, Medroxyprogesterone Acetate, Middle Aged, Pain, Postmenopause, Proportional Hazards Models, Public Health Sciences Division, Sensitivity and Specificity


Estrogen plus progestin therapy increases breast cancer incidence and breast tenderness. Whether breast tenderness during estrogen plus progestin therapy is associated with breast cancer risk is uncertain.