The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain.

Publication Type:

Journal Article

Source:

Neural development, Volume 5, p.9 (2010)

Keywords:

2010, Adaptor Proteins, Signal Transducing, Animals, Basement Membrane, Basic Sciences Division, Branchial Region, Cell Movement, Cell Polarity, Center-Authored Paper, Choristoma, Gene Expression Regulation, Developmental, Laminin, Motor Neurons, Muscle, Skeletal, Mutation, Neuroepithelial Cells, PHENOTYPE, Protein Kinase C, Rhombencephalon, zebrafish, Zebrafish Proteins

Abstract:

The facial branchiomotor neurons of cranial nerve VII undergo a stereotyped tangential migration in the zebrafish hindbrain that provides an ideal system for examining the complex interactions between neurons and their environment that result in directed migration. Several studies have shown the importance of the planar cell polarity pathway in facial branchiomotor neuron migration but the role of apical-basal polarity has not been determined. Here we examine the role of the PAR-aPKC complex in forming the basal structures that guide facial branchiomotor neurons on an appropriate migratory path.