Natural history of CNS relapse in patients with aggressive non-Hodgkin's lymphoma: a 20-year follow-up analysis of SWOG 8516 -- the Southwest Oncology Group.

Publication Type:

Journal Article


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 27, Issue 1, p.114-9 (2009)


2009, Aged, Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Follow-Up Studies, Humans, Lymphoma, Non-Hodgkin, Middle Aged, Prognosis, Prospective Studies, Public Health Sciences Division, RECURRENCE, Risk Factors


To investigate the incidence, natural history, and risk factors predictive of CNS relapse in patients with de novo aggressive lymphomas and to evaluate the efficacy of CNS prophylaxis in patients with initial bone marrow (BM) involvement.