Myeloablative irradiation in non-human primates.

Publication Type:

Journal Article

Source:

Journal of medical primatology, Volume 38, Issue 6, p.425-32 (2009)

Keywords:

2009, Animals, Blood Platelets, Bone Marrow, Clinical Research Division, Cord Blood Stem Cell Transplantation, Dose-Response Relationship, Radiation, Female, Hematopoiesis, Macaca nemestrina, Neutrophils, Platelet Count, Radiation Dosage, Radiation Injuries, Whole-Body Irradiation

Abstract:

We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression with acceptable radiation-related side effects.