Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.

Publication Type:

Journal Article


Journal of virology, Volume 83, Issue 14, p.7353-6 (2009)


2009, Animals, CARCINOMA, Cell Line, Tumor, Center-Authored Paper, Electron Microscopy Core Facility, Gene Dosage, Genomics Core Facility, Human Biology Division, Humans, Male, MICE, Phylogeny, Prostatic Neoplasms, Retroviridae, Shared Resources, Virus Integration


The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearly identical in properties and sequence to XMRV isolated by others and consist primarily of a single clone of cells with at least 10 integrated copies of XMRV, warranting further study of a possible role for XMRV integration in carcinogenesis.