Multidisciplinary management of locally advanced rectal cancer: neoadjuvant approaches.

Publication Type:

Journal Article


Journal of the National Comprehensive Cancer Network : JNCCN, Volume 11, Issue 5, p.548-57 (2013)


2013, Clinical Research Division, June 2013


Although tumor biology and genomics of colon and rectal cancer are no different, patients with locally advanced rectal cancer (LARC) require neoadjuvant fluoropyrimidine-based chemoradiation and total mesorectal excision. In addition to known clinical risk factors, improved algorithms integrating molecular tools are needed to stratify patients with LARC to improve treatment outcomes and reduce acute and long-term toxicities. Simply combining newer systemic or targeted agents with standard treatment in all patients yielded little success but added toxicities. This article reviews the historical data, current standards of care, and ongoing research efforts regarding biomarkers, molecular imaging, and personalized genomic information.