Multi-Ancestral Analysis of Inflammation-Related Genetic Variants and C-Reactive Protein in the Population Architecture using Genomics and Epidemiology (PAGE) Study.

Publication Type:

Journal Article

Source:

Circulation. Cardiovascular genetics, Volume 7, Issue 2, p.178-88 (2014)

Keywords:

2014, April 2014, Center-Authored Paper, Public Health Sciences Division, Specimen Processing Core Facility

Abstract:

-C-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes, and obesity. We aimed to replicate previous CRP-SNP associations, assess whether these associations generalize to additional race/ethnicity groups, and evaluate inflammation-related SNPs for a potentially pleiotropic association with CRP.