MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study.

Publication Type:

Journal Article


Breast cancer research : BCR, Volume 11, Issue 6, p.R91 (2009)


2009, Aged, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, Collaborative Data Services Core Facility, Dietary Supplements, Epidemiology Core Facility, Female, folic acid, Genetic Predisposition to Disease, Humans, Methionine, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Nutrition Assessment Core Facility, Polymorphism, Single Nucleotide, Postmenopause, Public Health Sciences Division, Risk Factors, Shared Resources, Vitamin B Complex


The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been hypothesized to increase breast cancer risk. However, results have been inconsistent, and few studies have reported the association by menopausal status or by intakes of nutrients participating in one-carbon metabolism. Our aims were to investigate whether MTHFR C677T was associated with postmenopausal breast cancer risk and whether this relation was modified by intakes of folate, methionine, vitamins B(2), B(6), and B(12), and alcohol.