A mouse plasma peptide atlas as a resource for disease proteomics.

Publication Type:

Journal Article

Source:

Genome biology, Volume 9, Issue 6, p.R93 (2008)

Keywords:

2008, Alternative Splicing, Animals, Databases, Protein, Humans, MICE, Peptides, PLASMA, Protein Isoforms, PROTEOMICS, Public Health Sciences Division, Tandem Mass Spectrometry

Abstract:

We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.