A mouse plasma peptide atlas as a resource for disease proteomics.

Publication Type:

Journal Article


Genome biology, Volume 9, Issue 6, p.R93 (2008)


2008, Alternative Splicing, Animals, Databases, Protein, Humans, MICE, Peptides, PLASMA, Protein Isoforms, PROTEOMICS, Public Health Sciences Division, Tandem Mass Spectrometry


We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.