Molecular staging of malignant melanoma: correlation with clinical outcome.

Publication Type:

Journal Article


JAMA : the journal of the American Medical Association, Volume 280, Issue 16, p.1410-5 (1998)


Adult, Aged, Cohort Studies, Female, Humans, Lymphatic Metastasis, Male, MELANOMA, Middle Aged, Monophenol Monooxygenase, Neoplasm Staging, Prospective Studies, Regression Analysis, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, RNA, Neoplasm, Skin Neoplasms, Survival Analysis


For most solid tumors, the metastatic status of regional lymph nodes is the strongest predictor of relapse and survival. However, routine pathological examination of lymph nodes may underestimate the number of patients with melanoma who have nodal metastases.