Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors.

Publication Type:

Journal Article

Source:

Gut, Volume 58, Issue 5, p.661-7 (2009)

Keywords:

2009, Adaptor Proteins, Signal Transducing, Adult, Aged, Center-Authored Paper, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, diet, DNA Mismatch Repair, DNA-Binding Proteins, Female, Gene Frequency, Genotype, Germ-Line Mutation, Humans, Life Style, Male, Microsatellite Instability, Middle Aged, Mutation, Missense, Nuclear Proteins, Polymorphism, Genetic, Public Health Sciences Division, Risk Assessment, Risk Factors, United States

Abstract:

Germline mutations in DNA mismatch repair (MMR) genes cause Lynch syndrome colon cancers. Less understood is the risk of colon cancer associated with common polymorphisms in MMR genes and the potential interacting role of lifestyle factors known to damage DNA.