Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer.

Publication Type:

Journal Article

Source:

Journal of translational medicine, Volume 12, Issue 1, p.121 (2014)

Keywords:

2014, Center-Authored Paper, Clinical Research Division, June 2014, Proteomics Core Facility, Public Health Sciences Division

Abstract:

The use of autoantibodies for the early detection of breast cancer has generated much interest as antibodies can be readily assayed in serum when antigen levels are low. Ideally, diagnostic autoantibodies would be identified in individuals who harbored pre-invasive disease/high risk lesions leading to malignancy. Prospectively collected human serum samples from these individuals are rare and not often available for biomarker discovery. We questioned whether transgenic animals could be used to identify cancer-associated autoantibodies present at the earliest stages of the malignant transformation of breast cancer.