A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: impact on survival and bleeding complications.

Publication Type:

Journal Article


Cancer, Volume 110, Issue 5, p.1149-61 (2007)


Anticoagulants, Hemorrhage, Heparin, Low-Molecular-Weight, Humans, Neoplasms, Randomized Controlled Trials as Topic, Survival Analysis, Treatment Outcome, Warfarin


Preclinical evidence suggests that anticoagulants, in particular the low-molecular-weight heparins (LMWH), exert an antitumor effect, whereas clinical trials have reported conflicting results. The authors conducted a comprehensive, systematic review and meta-analysis of the evidence from randomized controlled trials (RCTs), to evaluate the impact of anticoagulants on survival and safety in cancer patients without venous thromboembolism.