Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 19, Issue 19, p.5351-60 (2013)

Keywords:

2013, Center-Authored Paper, Clinical Research Division, Experimental Histopathology Core Facility, Immune Monitoring Core Facility, November 2013, Specimen Processing Core Facility, Vaccine and Infectious Disease Division

Abstract:

The persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins in Merkel cell carcinoma (MCC) provides a unique opportunity to characterize immune evasion mechanisms in human cancer. We isolated MCPyV-specific T cells and determined their frequency and functional status.