Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Publication Type:

Journal Article


Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 19, Issue 19, p.5351-60 (2013)


2013, Center-Authored Paper, Clinical Research Division, Experimental Histopathology Core Facility, Immune Monitoring Core Facility, November 2013, Specimen Processing Core Facility, Vaccine and Infectious Disease Division


The persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins in Merkel cell carcinoma (MCC) provides a unique opportunity to characterize immune evasion mechanisms in human cancer. We isolated MCPyV-specific T cells and determined their frequency and functional status.