Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls.

Publication Type:

Journal Article

Source:

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume 44, Issue 2, p.164-6 (2009)

Keywords:

2009, Antigens, Polyomavirus Transforming, Human Biology Division, Humans, Male, Polyomavirus, Polyomavirus Infections, prostate, Prostatic Neoplasms, RNA, Messenger, RNA, Viral, Tumor Virus Infections

Abstract:

Merkel cell polyomavirus (MCV or MCPyV) is a recently discovered human polyomavirus that is implicated in the pathogenesis of Merkel cell carcinoma (MCC). Although the transmission route for MCV is not yet known, other polyomaviruses, such as BKV, cause non-malignant pathology in the urinary tract. Like MCC, prostate cancer predominantly affects the elderly. Furthermore, prostate cancers and premalignant precursors exhibit chronic inflammation, which suggests a possible infectious involvement. We therefore examined whether MCV might participate in the pathogenesis of prostate cancer.