Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 18, Issue 11, p.2807-13 (2009)


2009, Aged, Aged, 80 and over, Case-Control Studies, CHOLESTEROL, Cohort Studies, Humans, Male, Middle Aged, Placebos, Prognosis, Prospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health Sciences Division, Risk Factors


Several prospective studies suggest that use of cholesterol-lowering statin drugs is inversely associated with advanced stage and possibly high-grade prostate cancer. One study reported that men with low cholesterol had a lower risk of high-grade prostate cancer. Given these findings, we investigated the association between low serum cholesterol and prostate cancer risk in the Prostate Cancer Prevention Trial.