Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma.

Publication Type:

Journal Article

Source:

BMC cancer, Volume 13, p.578 (2013)

Keywords:

2013, December 2013, Public Health Sciences Division

Abstract:

Esophageal cancer is the sixth leading cause of cancer death worldwide; current early detection screening tests are inadequate. Esophageal balloon cytology successfully retrieves exfoliated and scraped superficial esophageal epithelial cells, but cytologic reading of these cells has poor sensitivity and specificity for detecting esophageal squamous dysplasia (ESD), the precursor lesion of esophageal squamous cell carcinoma (ESCC). Measuring telomere length, a marker for chromosomal instability, may improve the utility of balloon cytology for detecting ESD and early ESCC.