Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples.

Publication Type:

Journal Article


AIDS (London, England), Volume 24, Issue 5, p.737-44 (2010)


2010, Adult, African Continental Ancestry Group, Center-Authored Paper, Circumcision, Male, Female, Heterosexuality, HIV Infections, HIV Seronegativity, HIV-1, HIV-2, Humans, Male, Prospective Studies, Risk Factors, Sexual Behavior, Vaccine and Infectious Disease Division


Male circumcision reduces female-to-male HIV-1 transmission risk by approximately 60%. Data assessing the effect of circumcision on male-to-female HIV-1 transmission are conflicting, with one observational study among HIV-1-serodiscordant couples showing reduced transmission but a randomized trial suggesting no short-term benefit of circumcision.