Magnitude and breadth of a nonprotective neutralizing antibody response in an efficacy trial of a candidate HIV-1 gp120 vaccine.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 202, Issue 4, p.595-605 (2010)

Keywords:

2010, AIDS Vaccines, Antibodies, Neutralizing, Center-Authored Paper, Female, HIV Antibodies, HIV Envelope Protein gp120, HIV-1, Humans, Male, Neutralization Tests, Vaccine and Infectious Disease Division

Abstract:

A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against the vaccine antigens. Here we assessed the magnitude and breadth of neutralizing antibody responses in Vax004.