Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB-Mediated Inflammation in Macrophages.

Publication Type:

Journal Article

Source:

Circulation research, Volume 114, Issue 3, p.421-33 (2014)

Keywords:

2013, January 2014, Public Health Sciences Division

Abstract:

Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the progression of human atherosclerosis. However, definitive cell type-specific causation studies in vivo are lacking, and the molecular mechanisms of potential proatherogenic effects remain to be determined.