Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.

Publication Type:

Journal Article

Source:

Cancer cell, Volume 20, Issue 3, p.289-99 (2011)

Keywords:

2011, ADENOCARCINOMA, Adult, Aged, Aged, 80 and over, Animals, Antineoplastic Agents, Blood Proteins, Cell Line, Tumor, Center-Authored Paper, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genomics Core Facility, Humans, Lung Neoplasms, Male, mass spectrometry, MICE, Middle Aged, Molecular Sequence Data, Neuroendocrine Cells, Nuclear Proteins, October 2011, PROTEINS, Proteome, PROTEOMICS, Public Health Sciences Division, Quinazolines, Receptor, Epidermal Growth Factor, RNA Interference, RNA, Small Interfering, Shared Resources, Small Cell Lung Carcinoma, TRANSCRIPTION FACTORS, Tumor Markers, Biological

Abstract:

We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.