Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 102, Issue 18, p.1413-21 (2010)


2010, Aged, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Center-Authored Paper, Double-Blind Method, Estrogen Replacement Therapy, Estrogens, Conjugated (USP), Female, Humans, Incidence, Lung Neoplasms, Middle Aged, Postmenopause, Progestins, Public Health Sciences Division, United States, Women's Health


In the Women's Health Initiative (WHI) randomized controlled trial, use of estrogen plus progestin increased lung cancer mortality. We conducted post hoc analyses in the WHI trial evaluating estrogen alone to determine whether use of conjugated equine estrogen without progestin had a similar adverse influence on lung cancer.