A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.

Publication Type:

Journal Article

Source:

Cancer investigation, Volume 28, Issue 9, p.978-82 (2010)

Keywords:

Breast Neoplasms, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Receptor, erbB-2, Receptors, Estrogen, Receptors, Progesterone, Retrospective Studies, Tumor Markers, Biological

Abstract:

Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) -2.408 (PR) -1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R² of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.