Long-term use of acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs and risk of hematologic malignancies: results from the prospective Vitamins and Lifestyle (VITAL) study.

Publication Type:

Journal Article


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 29, Issue 17, p.2424-31 (2011)


2011, Acetaminophen, Aged, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Clinical Research Division, Cohort Studies, Female, Hematologic Neoplasms, Humans, Life Style, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Public Health Sciences Division, RISK, Sex Characteristics


Among previous studies examining the associations of over-the-counter analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) and incident hematologic malignancies, results were inconsistent for NSAIDs but suggested an increased risk with acetaminophen (paracetamol). Herein, we used a large prospective cohort study to examine these associations.