Long-term tolerance to kidney allografts after induced rejection of donor hematopoietic chimerism in a preclinical canine model.

Publication Type:

Journal Article

Source:

Transplantation, Volume 94, Issue 6, p.562-8 (2012)

Keywords:

2012, Clinical Research Division, September 2012

Abstract:

Allogeneic hematopoietic cell transplantation provides a reliable method for inducing tolerance toward solid organ grafts. However, this procedure can result in graft-versus-host disease, thereby limiting its application. Here, we test the hypothesis that mixed chimerism can be intentionally reverted to host hematopoiesis without rejection of a kidney graft.