Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 101, Issue 13, p.946-58 (2009)


2009, Adolescent, Adult, Center-Authored Paper, Central Nervous System Neoplasms, Child, Child, Preschool, Clinical Research Division, Cohort Studies, Cranial Irradiation, Educational Status, Employment, Female, Humans, Incidence, Income, Infant, Infant, Newborn, Male, Marriage, Neoplasms, Second Primary, Odds Ratio, Population Surveillance, Proportional Hazards Models, Public Health Sciences Division, Quality of Life, Questionnaires, Radiation Injuries, Research Trials Office Core Facility - Biostatistics Service, Retrospective Studies, Shared Resources, Siblings, Time Factors, Treatment Outcome, United States, Young Adult


Adult survivors of childhood central nervous system (CNS) malignancies are at high risk for long-term morbidity and late mortality. However, patterns of late mortality, the long-term risks of subsequent neoplasms and debilitating medical conditions, and sociodemographic outcomes have not been comprehensively characterized for individual diagnostic and treatment groups.