Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group.

Publication Type:

Journal Article

Authors:

Ho, Phoenix A; Kutny, Matthew A; Alonzo, Todd A; Gerbing, Robert B; Joaquin, Jason; Raimondi, Susana C; Gamis, Alan S; Meshinchi, Soheil

Source:

Pediatric blood & cancer, Volume 57, Issue 2, p.204-9 (2011)

Keywords:

2011, Adolescent, Age Factors, Center-Authored Paper, Child, Child, Preschool, Clinical Research Division, DNA (Cytosine-5-)-Methyltransferase, DNA Methylation, Humans, Infant, Isocitrate Dehydrogenase, Leukemia, Myeloid, Acute, Mutation, Prevalence, September 2011, United States, Young Adult

Abstract:

Mutations in the DNMT3A, TET2, IDH1, and IDH2 genes carry prognostic significance and occur frequently in adult acute myeloid leukemia (AML). Leukemic mutations in all four genes have recently been implicated in aberrant DNA methylation, a hallmark of neoplasia. We previously reported that IDH1 mutations were absent, whereas TET2 mutations were present in 6%, of pediatric AML patients; in the present study, we determined the prevalence of DNMT3A and IDH2 mutations in pediatric AML.