Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.

Publication Type:

Journal Article

Source:

AIDS (London, England), Volume 29, Issue 13, p.1597-606 (2015)

Keywords:

Genomics Core Facility, Specimen Processing Core Facility

Abstract:

We have previously demonstrated robust control of simian/human immunodeficiency virus (SHIV1157-ipd3N4) viremia following administration of combination antiretroviral therapy (cART) in pigtailed macaques. Here, we sought to determine the safety of hematopoietic stem cell transplantation (HSCT) in cART-suppressed and unsuppressed animals.