Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies.

Publication Type:

Journal Article


Cancer causes & control : CCC, Volume 21, Issue 6, p.847-51 (2010)


2010, Aged, C-Reactive Protein, Center-Authored Paper, Epidemiologic Studies, Humans, Laboratory Techniques and Procedures, Male, Middle Aged, Prospective Studies, Public Health Sciences Division, Research


Data on long-term intra-individual variability in high-sensitivity C-reactive protein (hsCRP) are needed to determine whether one measurement adequately reflects usual levels in prospective studies of on the etiology of cancer and other chronic diseases; when not reflective, the ability to statistically detect modest to moderate associations is reduced. The authors estimated the size of this source of variability and consequent attenuation of the relative risk (RR).