Intensified postgrafting immunosuppression failed to assure long-term engraftment of dog leukocyte antigen-identical canine marrow grafts after 1 gray total body irradiation.

Publication Type:

Journal Article

Authors:

Sorror, Mohamed L; Leisenring, Wendy M; Mielcarek, Marco; Baron, Frederic; Diaconescu, Razvan; Hogan, William J; Graves, Scott S; Storb, Rainer

Source:

Transplantation, Volume 85, Issue 7, p.1023-9 (2008)

Keywords:

2008, Animals, Antibody Formation, Blood Transfusion, Bone Marrow Cells, Bone Marrow Transplantation, Center-Authored Paper, Clinical Research Division, Comparative Medicine Core Facility, Dogs, Experimental Histopathology Core Facility, Flow Cytometry Core Facility, Graft Rejection, Graft Survival, Histocompatibility Antigens, Immunosuppression, Lymph Nodes, Lymphocyte Count, Research Trials Office Core Facility - Biostatistics Service, Shared Resources, Sheep, Transplantation Chimera, Transplantation, Homologous, Whole-Body Irradiation

Abstract:

Late graft rejection after conditioning with 1 Gy of total body irradiation (TBI) was consistently seen in historical dogs given two postgrafting immunosuppressive drugs.

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