Integrative proteomic analysis of serum and peritoneal fluids helps identify proteins that are up-regulated in serum of women with ovarian cancer.

Publication Type:

Journal Article

Source:

PloS one, Volume 5, Issue 6, p.e11137 (2010)

Keywords:

2010, Ascitic Fluid, Blood Proteins, Center-Authored Paper, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin-Like Growth Factor Binding Protein 1, mass spectrometry, Ovarian Neoplasms, PROTEOMICS, Proteomics Core Facility, Public Health Sciences Division, Shared Resources, Up-Regulation

Abstract:

We used intensive modern proteomics approaches to identify predictive proteins in ovary cancer. We identify up-regulated proteins in both serum and peritoneal fluid. To evaluate the overall performance of the approach we track the behavior of 20 validated markers across these experiments.