Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival.

Publication Type:

Journal Article

Source:

Molecular cancer, Volume 9, p.143 (2010)

Keywords:

2010, Adult, Aged, Aged, 80 and over, Area Under Curve, Carcinoma, Squamous Cell, Center-Authored Paper, Clinical Research Division, Female, Gene Dosage, gene expression, Gene Expression Profiling, Genotype, Humans, Male, Middle Aged, Mouth Neoplasms, Polymorphism, Single Nucleotide, Principal Component Analysis, Proportional Hazards Models, Public Health Sciences Division, Research Trials Office Core Facility - Biostatistics Service, RNA, Messenger, ROC Curve, Shared Resources, Young Adult

Abstract:

Lymphotropism in oral squamous cell carcinoma (OSCC) is one of the most important prognostic factors of 5-year survival. In an effort to identify genes that may be responsible for the initiation of OSCC lymphotropism, we examined DNA copy number gains and losses and corresponding gene expression changes from tumor cells in metastatic lymph nodes of patients with OSCC.