Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 101, Issue 1, p.48-60 (2009)


2009, Age Factors, Aged, Blood Glucose, Body Mass Index, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, estradiol, Estrogen Replacement Therapy, Female, Humans, Hyperinsulinism, Insulin, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Middle Aged, Multivariate Analysis, Obesity, Odds Ratio, Postmenopause, Proportional Hazards Models, Prospective Studies, Public Health Sciences Division, Risk Assessment, Risk Factors, Shared Resources, Specimen Processing Core Facility, Statistics, Nonparametric, Tumor Markers, Biological


The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level.