Insights into leukemia-initiating cell frequency and self-renewal from a novel canine model of leukemia.

Publication Type:

Journal Article

Source:

Experimental hematology, Volume 39, Issue 1, p.124-32 (2011)

Keywords:

2011, Animals, Cell Line, Tumor, Center-Authored Paper, Clinical Research Division, Disease Models, Animal, Dogs, Flow Cytometry Core Facility, LEUKEMIA, MICE, Mice, Inbred NOD, Mice, SCID, Neoplasm Transplantation, Neoplastic Stem Cells

Abstract:

Leukemia-initiating cells (LICs) have been the subject of considerable investigation because of their ability to self-renew and maintain leukemia. Thus, selective targeting and killing of LICs would provide highly efficient and novel therapeutic strategies. Here we explored whether we could use a canine leukemia cell line (G374) derived from a dog that received HOXB4-transduced repopulating cells to study leukemia in the murine xenograft model and the dog.