Influence of estrogen plus testosterone supplementation on breast cancer.

Publication Type:

Journal Article


Archives of internal medicine, Volume 169, Issue 1, p.41-6 (2009)


2009, Aged, Analysis of Variance, Breast Neoplasms, Carcinoma, Ductal, Breast, Case-Control Studies, Center-Authored Paper, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, estradiol, Female, Follow-Up Studies, Hormone Replacement Therapy, Humans, Kaplan-Meier Estimate, Mammography, Methyltestosterone, Middle Aged, Postmenopause, Prevalence, Probability, Proportional Hazards Models, Public Health Sciences Division, Reference Values, Retrospective Studies, Risk Assessment, Survival Rate


Concern that the use of exogenous testosterone may increase breast cancer risk coexists with rising use of this medication in the United States. We sought to examine the relationship between the use of estrogen plus testosterone (E + T) therapy (esterified estradiol plus methyltestosterone) and the occurrence of breast cancer.