Infant safety during and after maternal valacyclovir therapy in conjunction with antiretroviral HIV-1 prophylaxis in a randomized clinical trial.

Publication Type:

Journal Article

Source:

PloS one, Volume 7, Issue 4, p.e34635 (2012)

Keywords:

2012, May 2012, Vaccine and Infectious Disease Division

Abstract:

Maternal administration of the acyclovir prodrug valacyclovir is compatible with pregnancy and breastfeeding. However, the safety profile of prolonged infant and maternal exposure to acyclovir in the context of antiretrovirals (ARVs) for prevention of mother-to-child HIV-1 transmission (PMTCT) has not been described.