Incremental benefits of screening colonoscopy over sigmoidoscopy in average-risk populations: a model-driven analysis.

Publication Type:

Journal Article

Authors:

Jeon, Jihyoun; Meza, Rafael; Hazelton, William D; Renehan, Andrew G; Luebeck, E. Georg

Source:

Cancer causes & control : CCC, Volume 26, Issue 6, p.859-70 (2015)

Abstract:

Screening colonoscopy and flexible sigmoidoscopy (FSG) reduce the risk of colorectal cancer (CRC), but the magnitude and duration of protection, particularly against right-sided cancer, remain uncertain. We computed the incremental benefit of colonoscopy over FSG using a validated mathematical model, which reflects colorectal neoplasia growth characteristics while allowing uncertainty in endoscopic detection and removal of adenomas.