Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma.

Publication Type:

Journal Article


Haematologica, Volume 95, Issue 4, p.597-603 (2010)


2010, Cell Proliferation, Center-Authored Paper, Chromosomes, Human, Pair 8, GENE AMPLIFICATION, Gene Dosage, Genes, myc, Humans, Immunoenzyme Techniques, In Situ Hybridization, Fluorescence, Ki-67 Antigen, Lymphoma, Large B-Cell, Diffuse, Proto-Oncogene Proteins c-myc, Public Health Sciences Division, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, Tissue Array Analysis, Translocation, Genetic


Translocations involving the MYC gene and increased MYC mRNA levels are associated with poor outcome in diffuse large B-cell lymphoma. However, the presence of increased MYC gene copy number and/or polysomy of chromosome 8 have not been previously described.