Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma.

Publication Type:

Journal Article

Source:

Haematologica, Volume 95, Issue 4, p.597-603 (2010)

Keywords:

2010, Cell Proliferation, Center-Authored Paper, Chromosomes, Human, Pair 8, GENE AMPLIFICATION, Gene Dosage, Genes, myc, Humans, Immunoenzyme Techniques, In Situ Hybridization, Fluorescence, Ki-67 Antigen, Lymphoma, Large B-Cell, Diffuse, Proto-Oncogene Proteins c-myc, Public Health Sciences Division, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, Tissue Array Analysis, Translocation, Genetic

Abstract:

Translocations involving the MYC gene and increased MYC mRNA levels are associated with poor outcome in diffuse large B-cell lymphoma. However, the presence of increased MYC gene copy number and/or polysomy of chromosome 8 have not been previously described.