Increased levels of HIV-1-infected cells in endocervical secretions after the luteinizing hormone surge.

Publication Type:

Journal Article

Source:

Journal of acquired immune deficiency syndromes (1999), Volume 47, Issue 5, p.529-34 (2008)

Keywords:

2008, Adult, CD4 Lymphocyte Count, Cervix Uteri, DNA, Viral, Female, HIV Infections, HIV-1, Human Biology Division, Humans, Luteinizing Hormone, Menstrual Cycle, Public Health Sciences Division, Vagina, Viral Load, Viremia, Virus Shedding

Abstract:

Levels of HIV-1 RNA in endocervical specimens fluctuate with the menstrual cycle, suggesting that cell-free HIV-1 levels may vary during the cycle, which could influence infectivity. Here, we examined daily changes in endocervical HIV-1-infected cells during 1 cycle. There were significant positive associations between the number of days from the luteinizing hormone surge and the number of HIV-1 DNA copies/swab (P = 0.001) and the number of total cells/swab (P < 0.001) in endocervical specimens. These data suggest that sampling of cell-associated endocervical HIV-1 increases after the periovulatory period, which could result in increased exposure to HIV-1-infected cells during sexual contact.