An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.

Publication Type:

Journal Article

Source:

Arteriosclerosis, thrombosis, and vascular biology, Volume 31, Issue 8, p.1916-26 (2011)

Keywords:

2011, Center-Authored Paper, Public Health Sciences Division, September 2011

Abstract:

Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity.